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How to account for hallucinations in the interpretation of the antidepressant effects of psychedelics: a translational framework


Web link: link.springer.com/10.1007/s...

Pages: 1853-1879

Abstract

Rationale Recent trials with psychedelics in major depressive disorder and treatment-resistant depression showed remarkable improvements in depressive symptoms that can last for up to several months after even a single administration. The lack of an appropriate placebo control group—as patients are often able to discriminate the subjective effects of the drug—and an incomplete understanding of the role of the hallucinogenic and mystical experience, hampers the interpretation of these therapeutic effects.