This paper will highlight some of primary evidence for entheogenic plant use in Islamic cults that partake of a vastly older legacy of ritual plant use. The accumulated research on entheogens and religions demands that certain traditions be reevaluated in light a continuing and coherent symbolism that enshrines holy plants as high mysteries in diverse faiths. Following the soma/haoma complex through Asia and Chinese Shamanism and into Persian and Islamic cults the use of entheogens meets with traditions in the ancient Middle East that shared doctrines of magic plants and cup rituals of visionary wine. The Greek, Semitic and Hermetic traditions merge with the shamanic techniques that persist in the esoteric symbolism of the Shia Muslims and Sufi as demonstrated in their holy books, art and poetry. The alchemical tradition thus emerges has having a definite entheogenic context that was cherished and protected by initiates from the profane. This speculative hypothesis rests on the collective evidence of religious traditions surrounding Islam that possessed similar rituals and reverence for plants that becomes a hidden aspect of mystical Islam. Keywords: Shia, Sufi, Soma, Hoama, entheogen, Amanita muscaria.