This dissertation research study employed a hermeneutic phenomenological approach to explore the researcher’s lived experience of using the shamanic plant medicines ayahuasca and Willka. Ayahuasca and Willka are classified as entheogens, chemical substances ingested for spiritual or healing purposes, and are used as central components of shamanic healing rituals in Peru. Data were collected via narrative methods of qualitative inquiry based on the researcher’s personal experiences with ayahuasca and Willka in Peruvian shamanic rituals. The researcher was the only participant in this study. Analysis of written protocols evaluated how these plants have contributed to the researcher’s overall healing process. Hermeneutic phenomenological analysis of the researcher’s written narratives were utilized with incorporation of relevant texts pertaining to mind-body research. The results of this study highlight the role of set and setting, heightened physical and emotional sensations and awareness, altered states of consciousness, a personal relationship with the sacred plants, expanded consciousness and enhanced self-knowledge and self-healing in facilitating health and well-being. This dissertation research study provides insight into the healing potential of shamanic sacred plant medicine and altered states of consciousness in modern health care.