In 1903, a Colombian naturalism, the Rafael Zerda Bayon, returning from a scientific mission to explore through the poorly known territories of the Colombian Caqueti and Putumayo, with a rich harvest of plant materials and documents, a strange and wonderful legenda: yage (*). He isolated a raw alkaloid by means of wealth, which, for reasons which he, as we will see later, called unespectedly as telepathine. The interest awakened by this “plant to the prophets” prompted other Colombian researchers to resume its study. G. Fischer Cardenas, in 1923, made it the subject of a short thesis of medicine. Mrs. Georgina Munoz v. in the same time, De Saunas began a series of interessed psycho-physiological tests that will soon be public. In short, the complete, methodical and thorough yajé study is to be done. It is a new subject that is not lacking in interest. This drug is a good experimental and investigative agent for the study of the exercise and functions of the various brain faculties; mechanism of memory, production of hallucinations and dreams, etc. Handled properly, it can be an excellent instrument, as a detector of the human subconscious, especially in the research of psychoanalysis, and contribute to the increase in our knowledge of the still unexplored and so obscure zons of human psyche. Recently Professor Barriga Villalba of the University of Bogota, with abundant materials, resumed and pushed further the chemical study of yage. He isolated in crystallised state, and studied the first, the alkaloid of Zerda Bayon, whose name he changed to the most appropriate yageine (*). He also discovered a second one, called yagenin. This is the translation of his work published in the Boletin of the Sociedad Colombiana de Cieneias Naturales de Bogota, March 1923, which we give below.