1. In the following of therapeutic studies, self-tests were carried out with harmine, which are to be filled for the first time the gap between clinical observations on the sick bed and pharmacological results on the animal. 2. Based on the physiological effect image, an excitation of the motor-sized cells in the cortex is assumed, but this acts on it merely as a physiological stimulation gene and is performed independently of the activation of the psychic personality. 3. With regard to the theoretical and practical significance of the harmine, it is also pointed out to its pharmacological classification. The harmine is therefore a special position as a pure motor poison in its distinction to caffeine in the series of centrally exciting varicose guilts. 4. The indication area of the harmine mainly refers to the corresponding organic disorders after the expectation of the psychological change has not been established. But the search attempts continue in this direction.