With this note I intend to highlight what I interpret as a significant testimony of the use of hallucinogenic plants, in this case mushrooms, by the ancient populations who lived in the Sahara, at a time when this vast territory was covered with a rich plant mantle. It is difficult to formulate hypotheses on the species of fungi depicted, whose biochemical characteristics depends partly on the type of experience induced on the human mind, belonging to a flora that has disappeared or withdrawn from the Saharan basin today desertified. From paintings it seems to be deductible the presence of at least two species, one of small size, often equipped with a "papillata" shape at the upper end, characteristic of most of the hallucinogenic Psilocybe currently known, and another of large dimensions (Boletus or Amanita).