In recent years, a plant, whose relationship with man is very old, has received renewed attention by enteogenic psychonators: Peganum Harmala. And this is not so much for its psychoactive properties, as for its synergic potential when mixed with other psychoactive plants, especially enteogenic plants. As a known plant used in the ancient cultures of the Mediterranean and the Middle East, it is not possible to exclude whether these associations or some of them have already been discovered and exploited.