The use of some drugs, such as cannabis and cocaine, has grown in important ways in recent years. The use of other substances has remained constant or has been reduced, as in the case of the legal ones, alcohol and tobacco. The interest in new drugs has kept growing in the last years among the youth. The access to Internet and the emergence of the pro-cannabis movement have facilitated this. In this paper we analized the characteristics of some not very well-known drugs and other substances which deserve special consideration at this precise moment. We examined the new and old synthetic drugs, the increase in the consumption of hydroponic cannabis, liquid ecstasy or GHB, ketamine, enteogens, ayahuasca and the possible increase in heroine consumption. We conclude that never has drug use reached such high levels, especially among the youth. We analyzed the underlying causes of this consumption and the need for health professionals to develop effective preventive and treatment programs for the people with addiction and dependence of the different psychoactive drugs.