This paper develops theoretical and epistemological elements that the author has been building in his doctoral thesis research: Networks and social groups associated with the consumption of Yage in the Coffee-Growing Region, since 2004 and with some background work since 2001, in order to describe and ground explanations in the context of American Indian and urban intercultural relations of the ritual consumption of yagé of Amazonian ancestry, “discovered” by Western science less than two centuries ago and adapted to new socio-cultural environments. New explanations from particular theoretical revisions especially anthropological, ethnopsychological and sociological, are carried out. The article ethnographically describes, supporting the above-mentioned, experiences of altered states of consciousness, visions and symbolic images that emerge communicatively within what might be called the paralinguistic yagé language, all of which has been promoting more or less permanently, cross-cultural dialogue among the participants, mainly non-indigenous people of varying social status, age or gender, in a context of emerging identities and mestizo and hybrid mentalities in the regional urban neoshamanistic context, in the Coffee-Growing Region of the Colombian Andes. Key words: Yage, cross-culturality, identities, emerging mentalities, Coffee-Growing Region, neoshamanism.