As a conclusive outlook, we will note that the bipartite organisation of our opinion considering first of all the chemical and pharmacological properties of the decoration and then the interpretations of ayahuasca in shamanic contexts enabled us to highlight and distinguish on one side the natural meaning of the object studied and on the other side its symbolic meaning. The historical and ethnological approach empirically describing the uses and successive cultural reinterpretations of the plant then highlighted the sociogenesis of the symbolic ayahuasca. In other words, while the vomitive and hallucinogenic effects of decoration are natural realities, the symbolic, sometimes teaching, sacralized, visionary, psychoanalytic or entheogenic effects of the plant is the result of socio-cultural construction and collective projections. However, systematically ritualized consumption of beverage raises the following question (perhaps trivial) : why is drugs here interpreted mystically/spiritual? The reason seems to be on the side of the intrinsic qualities of the substance. The hallucinogenic effects of the mixture would strengthen the neoplatonic idea of a separation between body and soul and belief in a suprasensory reality. Drugs would thus facilitate interactions with a presumed supernatural dimension of reality. Visions and revelations would then result from an attempt to give meaning and order the hallucinations produced by the psychotropic; these mental projections would establish and reconfigure on the basis of contextual and cultural heritage. While being produced from culture, the symbolic would in turn generate culture; this is the case of the multi-directional process of shamanic influences and interpretations of ayahuasca.