This article focuses on the use of Bufo alvarius psychoactive secretions. This practice that is growing in popularity nowadays carries with it risks and controversies. To amplify the knowledge about the traditional use of this preparation, we systematically review the texts on Bufo alvarius indexed by PubMED, Web of Science y Scopus. Furthermore, made the literary review and searched for evidence about the ritual use of anurans in the pre-Columbian codices and books of missionaries and conquerors. Our results show that there is no literary evidence about the tradition of Bufo alvarius ritual use. The rituals organized in the last time are products based on a neo shamanic invention. Keywords: Bufo alvarius, 5-MeO-DMT, tryptamines, ritual.