Although Ayahuasca and its psychoactive ingredients are interesting new substances for the treatment of depression, caution is advisable when it is patients with mania or psychosis in history or family history. Tourists participating in ayahuasca rituals should be informed in advance and then also be informed about the possible adverse psychiatric effects, in particular about ayahuasca-induced psychoses. Treatment with atypical antipsychotics (here olanzapine) appears to be effective in ayahuasca-induced psychosis.