Adverse childhood experiences can result in enormous lifetime consequences for exposed individuals, influencing their emotional and physical well-being as well as interpersonal relationships and life directions. The high complexity of symptoms among this group presents a major challenge to standard therapeutic approaches, and there is evidence that ayahuasca may be a useful adjunct to such treatments. Particularly beneficial could be its ability to simultaneously address a broad range of emotional, cognitive, and neurobiological impacts. However, the highly vulnerable nature of this group confirms the need for caution. Although offering promise, there is a need for further research investigating the extent to which proposed benefits occur in practice, as well as potential risks and strategies to best minimize these.