Clinical researchers are now working to develop psychedelic technologies for the treatment of mental health disorders. The acute attention to the importance of extrapharmacological factors in the psychedelic experience distinguishes the recent wave of clinical research on these substances from that of the 1950s. This opens up the prospect of a systematic exploration of extra-pharmacological factor in the psychedelic experience, the arrangement of which constitutes “psychedelic technologies”. This could allow us to better understand which specific factor transforms a certain aspect of the psychedelic experience and thus influences the user’s experience and subsequent worldview. This better understanding of the dynamic of the psychedelic experience could lead to the development of more accurate and effective psychedelic technologies. Finally, indigenous associations support themselves the political use of Amazon knowledge. Based on Convention 169 of the General Conference of the International Labour Organization, held in Geneva in 1989, the protection of the spiritual bond that collectively peoples establish with the territory, as set out in paragraph 13 of the Treaty. Respect for the territory and indigenous spirituality are evidently evident as two faces of the same phenomenon and confirming that possible access to progress, starting from their cultural roots, indigenous leaders are engaged in the promotion of awareness laboratories aimed at the natural Amazonian knowledge and its application in confronting the challenges imposed by modernity.