In the present article, I propose that it may be useful to think of ingestion of some common dietary ingredients as a form of microdosing. There are three parts to this hypothesis: First, that common dietary ingredients have psychoactive properties; second, that they converge (at least in part) to regulate molecular pathways shared by drugs that alter consciousness; and third, that via these mechanisms, combinations of dietary ingredients can produce synergistic potentiation of central nervous system (CNS) effects.