Data on the ethnopharmacology of ritual fumigatories in Middle and South America are summarized in table format. A literature search has yielded twenty-two plant species belonging to fifteen different genera as established or suggested ingredients of ritual fumigatories among the natives in these regions. Seven species contain a psychoactive principle and may very well be effective when smoked, six species contain a psychoactive principle but their efficacy when smoked is uncertain, and nine plants have not been adequately proved to contain a psychoactive principle.