In addition to promising leads for treating PTSD, addictions, depression, and death anxiety, 21 st Century research at medical schools finds that with careful screening, insightful attention to the variables of set, setting, and dosage, psychedelic drug administration often facilitates significant spiritual experiences, meaningfulness, altruism, well-being, and similar prospiritual effects. This article calls for theologians, professors of religious studies, philosophy, sociology, and psychology to update their courses. It challenges leaders of religious organizations, ‘‘How can your institution incorporate these practices and benefit from them?’’ KEYWORDS: theology, psychedelics, entheogens, history, future, new religious movements, religious studies, mysticism, transcendence