There is little hope for dialogue between the drug tourists and the Amazonians whose traditions of ayahuasca use are linked in a matrix dealing with the moral order, with good and evil, with animals and humans, and with health and illness. This has little to do with the experiences and needs of people in industrial societies. Modernization and cultural change over the last century have destroyed the material base of many Amazonian traditional cultures. Must we now allow this final spiritual denudation? Must the fifteenth-century Conquest still continue? Only the boa knows...