Restrictions on dietary and behavioral regimes in spiritual practices across different cultures can be so radically different from each other that comparative approaches may strike readers as more than odd. Yet, this diversity also indicates how remarkable it is when a cultural group adopts the spiritual dietary restrictions of a different culture. The recent emergence and popularity of the indigenous Amazonian psychoactive drink ayahuasca among members of Western societies provides an example of how spiritual dietary practices may become reimagined and adapted within just a few decades. Ayahuasca is a shamanic medicine and religious sacrament that typically induces vomiting and visions or other non-ordinary sensory experiences. The practice of drinking ayahuasca is accompanied by a diversity of dietary regimes and related behavioral taboos in its different contexts of use across indigenous Amazonia.