Along with many positive stories, the many risks to ayahuasca seekers and ayahuasca culture make frequent headlines. At best, cultural misunderstanding about appropriate relationships between giver and receiver lead to misunderstandings.At worst, exploitative relationships threaten ayahuasca’s expanded free use. The possibilities of further repressive legislation, harmful media exposure, or senseless casualties are very real. Given ayahuasca’s global prominence and legal status in South America, we now have an opportunity to develop a post-prohibition model of ayahuasca safety and sustainability—one that protects the plants, improves the safety and reputations of people, and holds space to expand ayahuasca’s place in global culture across disciplines.