This paper examines Amerindian rock art recovered on an isolated boulder located on the slopes of Upuigma Tepuy in the Arauák River Valley in Bolívar State, southeastern Venezuela. We explore some ideas about the possible use of this boulder by the indigenous hunter-gatherers, both as a shelter and as a place for enacting ritual activities, in the wider context of the cultural landscape. Preliminary analysis suggests possible regional interrelationships of the pictograms and suggests the source of the red ocher used for the paintings which might have come from a mineral anomaly located close to the site. We stress the necessity of further systematic research into this phenomenon in view of the potential for encountering more pictograms as well as other valuable data which would contribute to a better understanding of the chronology and sociocultural context of the long-past humans in this area. Finally, we call for the protection of this remote site as a valuable heritage site.