Harmalol hydrochloride, in doses of gr. 4/5 hypodermically or grs. 8-12 by mouth, has a slight but definite effect in relieving muscular rigidity in parkinsonism. It has no beneficial effect on the tremor or on the mental condition and does not relieve salivation. In these doses it is well tolerated. It does not produce anything like so complete a relief of all symptoms as is effected by the alkaloids of the hyoscine group, but may be of some value as an adjuvant to these, in the treaqtment of parkinsonism.