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Possible interactions between 5-HT2A receptors and the endocannabinoid system in humans: Preliminary evidence of interactive effects of ayahuasca and endocannabinoids in a healthy human subject

journal Article

2018

Rafael Guimarães, dos Santos José Alexandre S., Crippa F.L., Osório J.M., Rocha G.N., Rossi C., Marchioni M.E.C., Queiroz G.O., Silveira Mauricio, Yonamine Jaime E.C., Hallak

DOI: 10.1097/JCP.0000000000000973 Share

Web link: www.scopus.com/inward/re...

Pages: 644 - 646

Abstract

Considering that the 5-HT2A receptor and the ECS are co-expressed in brain regions associated with emotional processing, it is plausible to speculate that an interaction among those systems could be related to the antidepressive and anxiolytic properties of ayahuasca. More research is needed to better understand the effects of ayahuasca in the ECS and its relation to anxiety and mood.