In conclusion, both the currently available scientific evidence on the acute and long-term effects of ayahuasca and the studies that employed it as a therapeutic tool with psychiatric populations suggest that ayahuasca is a substance with an acceptable physiological and psychological safety profile and with therapeutic potential (McKenna, 2004; Gable, 2007; Bouso & Riba, 2011; Barbosa et al., 2012; dos Santos, 2013).