Although indigenous shamans and curanderos have known for centuries that Ayahuasca holds immense healing capacities and can dramatically transform a person’s life, science has been diligently trying to prove these assertions. Researchers have been investigating how this Amazonian plant can heal or have measurable impacts on a physical and psychological level. With the body of evidence growing, especially from Peru and other parts of South America, we can look forward to a future where Ayahuasca may be used therapeutically by mainstream medical professionals. Here we share some of what Ayahuasca research has taught us so far. For those who’ve experienced transformative experiences with this powerful medicine, we don’t have to explain that science doesn’t necessarily have all the answers when it comes to understanding this South American psychedelic plant. It is important to note that rigorous research with Ayahuasca is difficult to conduct in countries where it is not legal. Retreat Guru is dedicated to updating this article as more studies come out.