William Burroughs closed his classic debut novel, Junky, by saying he had determined to search out a drug he called 'Yage' which he believed transmitted telepathic powers, a drug that could be 'the final fix'. In The Yage Letters - a mix of travel writing, satire, psychedelia and epistolary novel - he journeys through South America, writing to his friend Allen Ginsberg about his experiments with the strange drug, using it to travel through time and space, to derange his senses - the perfect drug for the author of the wild decentred books that followed. Years later, Ginsberg writes back as he follows in Burroughs' footsteps, and the drug worse and more profound than he had imagined. In January 1953, William Burroughs began a seven-month expedition into the jungles of South America, ostensibly to find yage, the fabled hallucinogen of the Amazon. But Burroughs also cast his anthropological-satiric eye over the local regimes to record trademark vignettes of political and psychic malaise. From the notebooks he kept and the letters he wrote home to Allen Ginsberg, Burroughs composed a narrative of his adventures that appeared ten years later as “In Search of Yage” within The Yage Letters. That book, published by City Lights in 1963, was completed by the addition of Ginsberg’s account of his own experiences with yage as he traveled through South America in 1960, and by the addition of other Burroughs letters and texts.