The authors appreciate the careful reading and attention paid to the case report by Drs. Callaway et aI., and we agree thatadditional information regarding the circumstances ofthe overdose would provide clarification. Unfortunately the composition, dosage, and precise dosing timeframe for thedrugs in this case areunknown. Had they been available, they would have been included in the manuscript. As to the source ofthe 5-MeO-DMT, we are notprepared to speculate whether it was solely present in any "ooasca" preparations described in the investigation case notes or solely administered in synthetic form, as proposed by Dr. Callaway et al. Both scenarios deserve consideration, and we do not rule out either or a combined source based on the collected data. We agree with Dr. Callaway and colleagues thatAyahuasca deserves more attention. Through the presentation ofthis case, we hope to ensure that attention ispaid through legitimate study rather than additional toxicity reports.