1. Government regulations—Peru has implemented a national anti-wildlife trafficking policy, which includes jaguar trafficking (Supreme Decret N° 011-2017-MINA GRI) that punishes wildlife traffickers with a prison sentence of 3–5 years (SERFOR 2017), as established in article 308 of the 2016 Peruvian penal code. 2. Education of tourists—a formal media campaign to educate ayahuasca tourists on the plight of wild jaguars, and discouraging them from buying jaguar parts is urgently needed. 3. Regulate and sensitize shamanic tourism operations—we suggest that a concerted effort to formalize ayahuasca tourism and educate both tourists and tour operators could play an important role in discouraging the trade in this niche market. The shamans we encountered in Iquitos and Pucallpa stressed the importance of the jaguar to the Amazon ecosystem and as a powerful totem in the spiritual world. The leadership of ayahuasca retreats could be important champions for jaguar conservation in Peru, Costa Rica, Colombia, Brazil, and other regions where ayahuasca is used, and they could discourage tourists from using jaguar parts. 4. Bettered enforcement — enforcement by local police is limited and sellers in Peru, and traffickers are finding ways to hide the products in warehouses, in the back of their stalls and other locations. Bettered support and more resources are needed for anti-trafficking police in Peru.