This essay explore the globalization of Ayahuasca, a plant medicine endemic to the Upper Amazon. Originally distributed among only Indigenous Amazonian people, today it is distributed throughout the globe. Contemporara consumers of ayahuasca construct it not only as a medicine, but also as a religion sacrament, and as a drug. This essay benefits from information gathered during fieldwork the author personally conducted in the Peruvian Amazon and in the City of Cusco in October of 2009. Understanding the globalization of ayahuasca involves understanding of its contexts, which I explore before recounting ayahuasca's history. These contexts include: my own fieldwork on the subject, the relationship between Indigenous and Western cultures, the nature of ayahuasca, shamanism, and globalization itself. I discuss changes in ayahuasca's use and meaning and raise issues involved with its globalization. These include legal issues, commodification, and cultural appropriation. I recount the history of the globalization of ayahuasca, and in conclusion, revisit my hypothesis. This is a recent history, contributing fresh research to the bodies of scholarly work on ayahuasca, globalization, and indigenous religious practices as a whole. The globalization of ayahuasca is a contemporary phenomenon, coming only in the past decade, but like globalization itself it has deep roots. Ayahuasca is being globalized, but to reach the ranks of Coca-Cola and Marlboro cigarettes it still has a long way to go. Once found only in the Amazon basin, today it is distributed, produced, and consumed throughout the globe. Ayahuasca, and the ayahuasca experience, has become a commodity sold in both physical and virtual marketplaces. Cultural appropriation must be taken seriously, but with awareness that the reality is often more complex than a one-way transfer. Situating ayahuasca as a sacrament within a syncretic religion may be the best way to legalize its use for non-indigenous people. That said, indigenous uses and meanings should be acknowledged and remain primary. Aberto Manquiriapa represents hope that ayahuasca is staying true to its roots, but he also represents changes in indigenous shamanism. Ayahuasca is a powerful indigenous medicine — it may also be a good medicine for the modern world.