In this chapter, I draw upon ethnographic fieldwork conducted between 2007 and 2014 in mestizo and indigenous communities in the Huallaga, Paranapura, and Pastaza watersheds of the western Peruvian Amazon to explore the impacts of the ayahuasca boom for local peoples, I begin with an overview of the rise of the ayahuasca boom, tracing its history and linking it to other historical extractive booms in the Peruvian Amazon. Commodity booms radically altered sociality in Amazonia, especially among indigenous peoples, who often bore the brunt of asymmetric patron-client relationships and violence perpetuated by those leading extractive efforts. Yet, as Gow (1996) has cogently noted, these boom periods especially the rubber boom - while devastating for many, also created spaces for social creativity as a response to the myriad terrors experienced by Amazonian peoples, and ultimately, one of the sources of contemporary ayahuasca shamanism, or vegetalisnio. By situating the ayahuasca boom within the history of economic booms in Amazonia, I highlight the forms that have led to the diaspora of ayahuasca, as well as the controversies and benefits that have emerged within this milieu. Following this, I closely examine how shamanic tourism that is focused on the consumption of ayahuasca, and the ayahuasca boom more generally, has affected local peoples in both rural and urban Amazonian communities. In this discussion, I detail the multiple positive and negative impacts Amazonian peoples have experienced throughout the boom period.