The present study is one of the first bodies of research to examine the spiritual effects of ayahuacsac through a mixed design. Several other researchers have begun investigating the use of entheogens in a spiritual setting (Grob, 1996). If opportunities continue to exist for this type of research, further exploration in this area is necessary. In February 2006, in a case before the United States Supreme Court, the Court unanimously agreed to allow a congregation of one-hundred and thirty members of the Uniao do Vegetal to use ayahuasca as a religious sacrament. The Court argued that the government did not present a case of why ayahuasca should be treated differently then peyote as an exemption to the laws prohibiting Schedule I drugs use (Supreme Court of the United States, 2006). This leads the present researcher to believe there may be a movement towards acceptance of diversity of spiritual practices as healing tools in this country. As spirituality becomes more recognized as a valuable tool in people’s lives, changes may occur both in the clinical and political atmosphere that permit greater opportunities for personal spiritual growth. These opportunities will likely take on many forms, with the use of entheogens being one of them. Over recent years, ayahuasca has been shown to help people who use it in a spiritual setting to lead happier and healthier lives (Silverira, 2005). This current study shows that those who drink ayahuasca only one time tend to have positive, spiritual experiences during ceremonies and afterwards, and take these positive experiences and integrate them into their daily lives for some time. These ayahuasca ceremony participants tend to feel more connected to people, nature and god, feel more healed and peaceful, and carry a sense of peace with them deeper than prior to their ayahuasca ceremony experience.