This mixed-methods study researched people who have participated in traditional Indigenous Ayahuasca ceremonies to determine if the experience served as an antidote to dominant cultural hegemony. Fourty-four participants completed the quantitative scaled questionnaire and 11 qualitative interviews were conducted for the study. Findings reveal five antidotal movements toward countering the uninvestigated assumptions dictated by hierarchical systems common to Western culture. These include self-determination; increased relationality; reduced anthropocentrism; reduced consumerism/materialism; movement toward more critical awareness of status-quo assumptions. The most profound transformations toward counter-hegemonic dispositions occurred in concert with certain dynamics I describe relating to several variables. I conclude that working with ayahuasca moves people toward Indigenous ways of understanding the world. Keywords: Hegemony, Western hegemony, ayahuasca, Indigenous worldview