Shamanic use of sacred plants such as peyote, mushrooms, and ayahuasca serves to free the soul from corporeal confinement, facilitate access to realms of alternate reality, and allow communication with the spiritual world. These plants are also used to diagnose and treat a wide variety of illnesses, both psychological and physical. Ingestion of traditional sacred plants in connection with shamanic rituals often results in spiritual experiences. We can argue that some of these experiences qualify as travel into realms belonging to certain genres of science fiction such as horror, fantasy, and ghost stories. Participants in these rituals frequently report encounters with spiritual beings—some of them benevolent, some of them scary and threatening. Others experience time travel, telepathy, or merging with God. DMT often induces experiences that belong to hard science fiction or space opera. Almost 50 percent of the subjects participating in a clinical study conducted by Rick Strassman claimed to remain totally lucid while visiting absolutely alien realms. Some of them described seeing vast, orbital structures around unknown planets or meeting and interacting with peculiar alien beings. These contacts ranged from various attempts at communication to bizarre surgical procedures and even intercourse with aliens! Many of these reports parallel those of “alien abduction” literature, leading us to speculate about a relationship between endogenous DMT and such encounters.