Overall, the articles in this special issue highlight the relevance of considering social and cultural domains when attempting to explain the benefits of using psychedelic plant medicines. In parallel to such perspectives, the question of mitigating risks involved with psychedelic use would equally benefit from considering social and cultural parameters, as highlighted in some of the research articles above. Social groups and cultural contexts do not simply give meaning to the experiential properties of psychedelic substance use but are necessary ingredients for safely turning such properties into medicine.