In folk lore there is a belief that many people who have an acute psychotic breakdown exhibit signs of psychic ability. Research into this folk lore is virtually non-existent, but some interesting work by Neppe (1980) and Persinger (Persinger & Makarec, 1987) psi suggests that there might be some foundation for it. My research into the pineal gland is now exploring this same area from a neurochemical perspective. The pineal gland makes a neurohormone called melatonin which is one of the key regulators of the circadian and seasonal biological rhythms. It also makes a mono-amine oxidase (MAO) inhibitor called pinoline (Methoxytetrahydrobetacarboline (MeOTHBC)) which acts on the GABA receptors and whose chemical structure is virtually identical with the harmala alkaloids, which are key ingredients in the ayahausca drink used by Amazonian people specifically for inducing a state of consciousness in which they state that they go out-of- body, experience travelling clairvoyance, divination and shamanic healing. The suggested neurochemistry for these effects implicates serotonin. Serotonin (5 Hydroxytryptamine (5HT)) has frequently been implicated in certain aspects of psychoses. Pinoline is a neuromodulator which prevents, amongst other effects, the breakdown of serotonin. This results in an accumulation of physiologically active amines including dimethyltryptamine (DMT) within the neuronal synapses which may lead to hallucinations, depression or mania depending on the amines being affected (Strassman, 1990). DMT is the other main ingredient in ayahuasca. There are also interesting links with the serotonergic activation by psychedelics such as LSD, psilocybin and MDMA which have all been implicated in triggering psychotic episodes, and more specifically with inducing a state of consciousness which has many similarities with both an acute psychotic breakdown and with shamanism, which traditionally uses psychedelic plants in order to achieve the desired state of consciousness. A key link between all of these various experiences is the dream state of consciousness. Psychologically, both the shamanic initiation experience and that of an acute psychotic breakdown share many similarities with the dream state. It appears that the normal every night experience of all human beings is connected with the more extreme experiences of psychosis and shamanism through the same neurochemical pathways that underlie all these experiences. And, as the research at Maimonides (Ullman et al, 1975) and since has shown, the dream state is a psychic state of consciousness par excellence. This suggests that the anthropological reports of psychic abilities being exhibited by shamans may have some foundation, and suggests that some people who have experienced a psychotic breakdown could be seen in other cultures as people with a particular and highly valued gift - the gift of walking between the worlds