Elaborating on conversational exchanges with a Brazilian shaman about biopiracy and interweaving scholarly literature from the ontological and ‘botanical’ turn, the author examines the disciplinary as well as the political ramifications of plant healers and practitioners – particularly indigenous ones – going largely uncited in plant-centred discussions. In Brazil, indigenous claims for territory and political sovereignty gain traction when they are linked to cultural patrimony. Highlighting ayahuasca as an example of the way that certain plants and people can be involved in collaborative survival, the author demonstrates the entwined semiotic-material stakes of the botanical turn within claims for traditional knowledge and territory. Her analysis frames possible ethnobotanies and methodologies of refusal in respecting plant(ed)-human resistance.