The treatment of drug addiction is complex, and many of the approaches used today have low effectiveness, particularly when used alone. The pharmaceutical industry is still looking for more effective drugs and with less side effects, and among the possible alternatives are the herbal products. Many plants and active ingredients have been evaluated as potential for addiction treatment in preclinical studies, but few clinical studies have been conducted and just few herbal medicines were approved. This situation indicates that more clinical trials are needed to allow the development and use of herbal products in the treatment of drug dependence.