Psychedelics may hold the key to a novel PTSD treatment. The results presented in the study carried out by Dr. Kelley and colleagues advanced our knowledge regarding the validation of an animal model of PTSD and the expression of genes after psychedelic exposure. They also showed a decrease in the actual levels of ROS following psychedelic treatment, emphasizing the validity of their gene expression data. This study expands our understanding of PTSD and opens an avenue of developing effective psychedelic based treatment regimens for this disorder.