The extent to which ecocriticism can engage the early texts of William Burroughs is explored in order to identify the problems in attempting an ecocritical interpretation of the writer's experimental writing with its lack of coherent narratives and shortage of recognizably relevant environmental content. The suggestion that early cut-ups from Minutes to Go and The Yage Letters can be considered a move towards proto-ecological writing forms is explored. Example fragments from Burroughs' early cut-ups 'VIRUSES WERE BY ACCIDENT?' (1960) and 'I am Dying, Meester?' (1963) are examined to establish whether there are any connections between ecology and Burroughs' cut-up method, and to illustrate the evolution of the cut-up method. The Yage Letters are shown to connect the cut-up method and ayahuasca as radical techniques of reality transformation, which means the undoing of Western assumptions about identity. The differences between Burroughs methods and those of the Dadaist Tristan Tzara are also discussed.