Wood extracts of the Peruvian plant Virola calophylla Warb. (Myristicaceae) were shown to have antifeedant activity against the cotton boll weevil (Anthonomus grandis Boh.). Five compounds with antifeedant activity were isolated. They include 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 2-methyl-6-methoxytetrahydro-β-carboline (6-MeO-THC), nicotine, friedelan-3-one, and β-sitosterol.