N,N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD). Synthetic production of DMT as well as extraction from several plants of South American flora is possible. DMT might induce feelings of unity with the cosmos and experiences of eternity, and it is a natural content of a traditional South American beverage -ayahuasca-which is consumed at shamanistic rituals. There is not any data on the abuse of DMT in Turkey to date. We here present a case characterised by sudden and dramatic changes in the clinical features of a hypomanic episode induced after three years of cannabis use, immediately after consuming DMT due to the addition of psychotic features.