The new alkaloids (2S,5S)-2,5-dibenzyl-1,4-dimethylpiperazine, 8-hydroxy-4,7-dimethoxyfuranoquinoline, and 8-isopentenyloxy-4,7-dimethoxyfuranoquinoline were isolated from Zanthoxylum arborescens (Rutaceae). The β-D-glucopyranoside of hordenine (previously known only as a synthetic) was also found. The known alkaloids skimmianine, tembetarine, hordenine, N,N-dimethyltryptamine, N-methyltryptamine, 1-methyl-3-(2′-phenylethyl)-1H,3H-quinazoline-2,4-dione and 1-methyl-3-[2′-(4″-methoxyphenyl)ethyl]-1H,3H-quinazoline-2,4-dione also were isolated. Structure proof of the two new furanoquinoline alkaloids necessitated a revision in the previously suggested structure for perfamine, a cyclohexadienone alkaloid from Haplophyllum perforatum.