It is important to acknowledge that, although the above-mentioned results are promising, they are not conclusive evidence that ayahuasca can be used as an antidepressant. The results were observed only with single doses in few patients, and the depressive symptoms returned some weeks after ayahuasca intake. Thus, ayahuasca is not a cure for depression, and further studies using more doses in larger samples are necessary to evaluate its long-term efficacy and safety, especially with a view to use in adolescents. Future studies will also need to assess the possible advantages and disadvantages of ayahuasca in relation to traditional antidepressants, and in which specific subpopulations of patients with depression ayahuasca could be more helpful.