Exploring the historical, traditional, and entheogenic contexts of ayahuasca for further understanding of its therapeutic value. Psychedelics have been growing in popularity as numerous psychological studies explore the effectiveness in treating a variety of mental health issues, ranging from addiction to PTSD.1 Despite the increasing number of clinical trials of these substances, little sociological research has been conducted on the subject. It is important to understand the history of traditions behind the use of these entheogens. Like many other psychoactive compounds, there’s much debate as to whether a mystical experience is truly necessary for one to receive therapeutic benefits from ayahuasca. This article goes beyond the science, taking a closer look into the spiritual and ancestral aspects of ayahuasca use. A deeper look into these sociological aspects may be important to fully understand the psychological and spiritual healing potential of psychedelics.