The afterglow effect is commonly referenced in psychedelic literature. However, limited attention is being paid to several uncontrolled variables. The afterglow can essentially be understood as a persisting feeling of elevated and invigorated mood, accompanied by liberation from past concerns such as guilt and anxiety.1 An individual’s willingness to enter into close relationships with others may increase during the afterglow, and the efficacy of psychotherapeutic interventions are often enhanced. According to the scientist and clinician Walter Pahnke, the afterglow phenomenon lasts for a period of two weeks to a month before gradually subsiding. Evidence points to the afterglow period as ushering in far-ranging benefits.