New research provides insight into the debate centered around the brain's capacity to synthesize DMT endogenously. In the last couple of decades, there has been much debate within the scientific community over whether the mammalian brain produces DMT endogenously. And if so, is the compound produced in sufficient quantities to initiate the remarkable psychoactive effects observed when administered exogenously? A debate has also ensued concerning the role of the pineal gland – a tiny neuroendocrine organ in the brain whose primary function is nighttime secretion of melatonin – in the synthesis of DMT. This article will give a brief overview of the history and current findings of DMT biosynthesis and will also aim to contextualize these findings.