In reconstructing early uses of psychotogens in Mesoamerica, mushrooms have occupied the attention of botanists and anthropologists almost to the exclusion of other plant motifs. Not all of the images and literary fragments extant lend themselves to mycological interpretation. Some authors have interpreted the peltate leaves and flower buds of the psychotogen Nymphaea ampla as being green mushrooms and/or stalked sea shells. The context of presentation, information on the water lily in Maya antiquity, and recent information on the chemistry of this white water lily suggest that we must reassess the role of Nymphaea ampla. In a reevaluation of these ancient literary and iconographic sources, it would seem that both mushrooms and water lilies emerge as important ritual psychotogens. While the contextual use of mushrooms is well known, the water lily has been largely ignored. This presentation provides some perspective on both of these important New World narcotics.