Given that numerous groups used ayahuasca historically and we now have tantalizing evidence for it being present for at least 1,000 y, and given the complexity of the interaction of 2 different plants used to make ayahuasca, there are likely mysteries about how these plants work that may benefit modern people. Others have not missed this observation, and in fact there is debate in the pharmacology literature as to whether the various alkaloids in Banisteriopsis caapi might be effective in treating neurodegenerative disorders. It is good that research such as Miller et al.’s could further encourage medical science to reassess ayahuasca’s role in healing.