This interview examines the thinking and theoretical framework of Takiwasi’s main director Jacques Mabit. One interest of our questions was Mabit’s concept of health benefits and risks of ayahuasca use. Another emphasis was put on investigating the intriguing hybridization of Western psychotherapy and Amazonian traditional medicine that the Takiwasi Center employs to treat drug abuse. Moreover, the interview addresses several important questions about the effects of ayahuasca use on particular aspects of human health – a field of knowledge about which much remains to be learned.