A problem arising in attempting to assess the safety or danger of this kambô practice is that the numbers of practitioners are unknown and that internet sales are not monitored. Lack of formal training of practitioners may also be an issue that requires addressing as it has been suggested that inexperienced practitioners may incorrectly use the skin secretion of other species of amphibians such as the cane toad Rhinella marina. Finally it has also been suggested that the increasing use of kambô rituals may also have a negative impact upon the population numbers of Phyllomedusa bicolor in their native habitats in the forests of Bolivia, Peru, Brazil, the Guianas, Colombia and Venezuela.